Plant Transcription Factor Database
Previous version: v3.0
Tarenaya hassleriana
M-type_MADS Family
Species TF ID Description
XP_010521160.1M-type_MADS family protein
XP_010521161.1M-type_MADS family protein
XP_010521162.1M-type_MADS family protein
XP_010523118.1M-type_MADS family protein
XP_010523119.1M-type_MADS family protein
XP_010523638.1M-type_MADS family protein
XP_010523639.1M-type_MADS family protein
XP_010527496.1M-type_MADS family protein
XP_010527635.1M-type_MADS family protein
XP_010527914.1M-type_MADS family protein
XP_010528984.1M-type_MADS family protein
XP_010529151.1M-type_MADS family protein
XP_010530332.1M-type_MADS family protein
XP_010530689.1M-type_MADS family protein
XP_010533300.1M-type_MADS family protein
XP_010534379.1M-type_MADS family protein
XP_010535244.1M-type_MADS family protein
XP_010535250.1M-type_MADS family protein
XP_010535251.1M-type_MADS family protein
XP_010535252.1M-type_MADS family protein
XP_010535253.1M-type_MADS family protein
XP_010535254.1M-type_MADS family protein
XP_010535258.1M-type_MADS family protein
XP_010535624.1M-type_MADS family protein
XP_010539166.1M-type_MADS family protein
XP_010539972.1M-type_MADS family protein
XP_010539973.1M-type_MADS family protein
XP_010539974.1M-type_MADS family protein
XP_010539975.1M-type_MADS family protein
XP_010540558.1M-type_MADS family protein
XP_010541161.1M-type_MADS family protein
XP_010541168.1M-type_MADS family protein
XP_010545390.1M-type_MADS family protein
XP_010546777.1M-type_MADS family protein
XP_010547838.1M-type_MADS family protein
XP_010547911.1M-type_MADS family protein
XP_010547925.1M-type_MADS family protein
XP_010548803.1M-type_MADS family protein
XP_010548807.1M-type_MADS family protein
XP_010548848.1M-type_MADS family protein
XP_010548849.1M-type_MADS family protein
XP_010549187.1M-type_MADS family protein
XP_010549480.1M-type_MADS family protein
XP_010549481.1M-type_MADS family protein
XP_010549548.1M-type_MADS family protein
XP_010549549.1M-type_MADS family protein
XP_010549551.1M-type_MADS family protein
XP_010549566.1M-type_MADS family protein
XP_010549567.1M-type_MADS family protein
XP_010549568.1M-type_MADS family protein
XP_010551213.1M-type_MADS family protein
XP_010551435.1M-type_MADS family protein
XP_010551436.1M-type_MADS family protein
XP_010552915.1M-type_MADS family protein
XP_010555984.1M-type_MADS family protein
XP_010557539.1M-type_MADS family protein
XP_010557756.1M-type_MADS family protein
XP_010558896.1M-type_MADS family protein
XP_010558909.1M-type_MADS family protein
XP_010558910.1M-type_MADS family protein
XP_010558917.1M-type_MADS family protein
XP_010559252.1M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513